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        "resumen" => "<p class="elsevierStylePara"> ANTECEDENTES El pron&#243;stico del s&#237;ndrome de Takotsubo &#40;STT&#41; contin&#250;a siendo controvertido debido a la escasez de datos disponibles&#46; Adem&#225;s&#44; no se ha esclarecido todav&#237;a el efecto de los factores desencadenantes&#46;</p> <p class="elsevierStylePara"> OBJETIVOS En este estudio se compar&#243; el pron&#243;stico de pacientes con STT y con s&#237;ndrome coronario agudo &#40;SCA&#41; y se investigaron los resultados cl&#237;nicos a corto y largo plazo en el STT en funci&#243;n de los diferentes desencadenantes&#46;</p> <p class="elsevierStylePara"> M&#201;TODOS Se incluy&#243; en el estudio a pacientes con STT del <span class="elsevierStyleItalic">International Takotsubo Registry</span>&#46; Se compar&#243; la mortalidad a largo plazo de los pacientes con STT con la de una cohorte de pacientes con SCA emparejados por edad y sexo&#46; Se compararon asimismo los resultados cl&#237;nicos a corto y largo plazo de diferentes grupos de pacientes seg&#250;n los factores desencadenantes que mostraban&#46;</p> <p class="elsevierStylePara"> RESULTADOS En t&#233;rminos generales&#44; los pacientes con STT presentaron un riesgo de mortalidad a largo plazo comparable al de los pacientes con SCA&#46; De los 1613 pacientes con STT&#44; en 485 &#40;30&#37;&#41; se detect&#243; un desencadenante emocional&#46; De los 630 pacientes &#40;39&#37;&#41; con desencadenantes &#200;&#237;sicos&#44; 98 &#40;6&#37;&#41; ten&#237;an trastornos neurol&#243;gicos agudos&#44; mientras que en los otros 532 &#40;33&#37;&#41;&#44; los factores desencadenantes eran actividades &#200;&#237;sicas&#44; trastornos m&#233;dicos o intervenciones&#46; En los 498 pacientes restantes &#40;31&#37;&#41; no hab&#237;a ning&#250;n desencadenante identificable&#46; Los pacientes con un STT asociado a la tensi&#243;n &#200;&#237;sica mostraron unas tasas de mortalidad superiores a las de los pacientes con SCA durante el seguimiento a largo plazo&#44; mientras que los pacientes con un s&#237;ndrome asociado al estr&#233;s emocional presentaron una evoluci&#243;n cl&#237;nica mejor que la de los pacientes con SCA&#46;</p> <p class="elsevierStylePara"> CONCLUSIONES En t&#233;rminos generales&#44; los pacientes con STT tuvieron una evoluci&#243;n cl&#237;nica a largo plazo comparable a las de los pacientes con SCA de igual edad y sexo&#46; Demostramos&#44; adem&#225;s&#44; que el STT puede ser tanto un trastorno benigno como un trastorno que ponga en peligro la vida&#44; dependiendo de cu&#225;l sea el factor desencadenante&#46; Proponemos una nueva clasificaci&#243;n basada en los factores desencadenantes&#44; que puede ser una herramienta cl&#237;nica &#250;til para predecir la evoluci&#243;n a corto y a largo plazo del STT&#46; &#40;International Takotsubo Registry &#91;InterTAK Registry&#93;&#59; NCT01947621&#41; &#40;J Am Coll Cardiol 2018&#59;72&#58;874-82&#41; &#169; 2018 by the American College of Cardiology Foundation&#46; Publicado por Elsevier&#46;</p>"
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Pronóstico a largo plazo de los pacientes con síndrome de Takotsubo
Jelena R. Ghadria, Ken Katoa, Victoria L. Cammanna, Sebastiano Gilib, Stjepan Jurisica, Davide Di Vecea, Alessandro Candrevaa, Katharina J. Dinga, Jozef Miceka, Konrad A. Szawana, Beatrice Bacchia, Rahel Bianchia, Rena A. Levinsonc, Manfred Wischnewskyd, Burkhardt Seiferte, Susanne A. Schlossbauera, Rodolfo Citrof, Eduardo Bossonef, Thomas Münzelg, Maike Knorrg..., Susanne Heinerg, Fabrizio D’Ascenzoh, Jennifer Frankei, Annahita Sarconj, L. Christian Nappk, Milosz Jaguszewskil, Michel Noutsiasm, Hugo A. Katusi, Christof Burgdorfn, Heribert Schunkerto, Holger Thielep, Johann Bauersachsk, Carsten Tschöpeq, Burkert M. Pieskeq, Lawrence Rajanr, Guido Michelss, Roman Pfisters, Alessandro Cuneot, Claudius Jacobshagenu, Gerd Hasenfußu, Mahir Karakasv, Wolfgang Koenigo, Wolfgang Rottbauerw, Samir M. Saidx, Ruediger C. Braun-Dullaeusx, Adrian Banningy, Florim Cuculiz, Richard Kobzaz, Thomas A. Fischeraa, Tuija Vasankariab, K.E.. Juhani Airaksinenab, Grzegorz Opolskiac, Rafal Dworakowskiad, Philip MacCarthyad, Christoph Kaiserae, Stefan Osswaldae, Leonarda Galiutoaf, Filippo Creaaf, Wolfgang Dichtlag, Klaus Empenah, Stephan B. Felixah, Clément Delmasai, Olivier Lairezai, Ibrahim El-Battrawyaj, Ibrahim Akinaj, Martin Borggrefeaj, John Horowitzak, Martin Kozelal, Petr Tousekal, Petr Widimskýal, Ekaterina Gilyarovaam, Alexandra Shilovaam, Mikhail Gilyarovam, David E. Winchesteran, Christian Ukenaao, Jeroen J. Baxap, Abhiram Prasadaq, Michael Böhmao, Thomas F. Lüscherar, Frank Ruschitzkaa, Christian TemplinaVer más
a University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Suiza.
b University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Suiza. Division of Cardiology, Department of Medical Sciences, AOU Citta della Salute e della Scienza, University of Turin, Turín, Italia.
c University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Suiza. Division of Biological Sciences, University of California, San Diego, La Jolla, California.
d Department of Mathematics and Computer Science, University of Bremen, Bremen, Alemania.
e Department of Biostatistics, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Suiza.
f Heart Department, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italia.
g Cardiology 1, Center for Cardiology, University Medical Center Mainz, Mainz, Alemania.
h Division of Cardiology, Department of Medical Sciences, AOU Citta della Salute e della Scienza, University of Turin, Turín, Italia.
i Department of Cardiology, Heidelberg University Hospital, Heidelberg, Alemania.
j University of Southern California, Keck School of Medicine, Los Angeles, California.
k Department of Cardiology and Angiology, Hannover Medical School, Hannover, Alemania.
l First Department of Cardiology, Medical University of Gdansk, Gdansk, Polonia.
m Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle, Halle (Saale), Alemania.
n Heart and Vascular Centre Bad Bevensen, Bad Bevensen, Alemania.
o Deutsches Herzzentrum München, Technische Universität München, Munich, Alemania. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Alemania.
p Heart Center Leipzig, University Hospital, Department of Internal Medicine/ Cardiology, Leipzig, Alemania.
q Department of Cardiology, Charité, Campus Rudolf Virchow, Berlin, Alemania.
r TJ Health Partners Heart and Vascular, Glasgow, Kentucky.
s Department of Internal Medicine III, Heart Center University of Cologne, Colonia, Alemania.
t Krankenhaus “Maria Hilf” Medizinische Klinik, Stadtlohne, Alemania.
u Clinic for Cardiology and Pneumology, Georg August University Goettingen, Goettingen, Alemania.
v Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburgo, Alemania.
w Department of Internal Medicine II–Cardiology, University of Ulm, Medical Center, Ulm, Alemania.
x Internal Medicine/Cardiology, Angiology, and Pneumology, Magdeburg University, Magdeburg, Alemania.
y Department of Cardiology, John Radcliffe Hospital, Oxford University Hospitals, Oxford, Reino Unido.
z Department of Cardiology, Kantonsspital Lucerne, Lucerna, Suiza.
aa Department of Cardiology, Kantonsspital Winterthur, Winterthur, Suiza.
ab Heart Center, Turku University Hospital and University of Turku, Turku, Finlandia.
ac Department of Cardiology, Medical University of Warsaw, Varsovia, Polonia.
ad Department of Cardiology, Kings College Hospital, Kings Health Partners, Londres, Reino Unido.
ae Department of Cardiology, University Hospital Basel, Basilea, Suiza.
af Department of Cardiovascular Sciences, Catholic University of the Sacred Heart Rome, Roma, Italia.
ag University Hospital for Internal Medicine III (Cardiology and Angiology), Medical University Innsbruck, Innsbruck, Austria.
ah University Medicine Greifswald, Department of Internal Medicine B, Greifswald, Alemania. DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Alemania.
ai Department of Cardiology and Cardiac Imaging Center, University Hospital of Rangueil, Toulouse, Francia.
aj First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM) University of Heidelberg, Mannheim, Alemania. DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim, Manheim, Alemania.
ak Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide, Adelaida, Australia.
al Charles University in Prague and University Hospital Kralovske Vinohrady, Praga, República Checa.
am Intensive Coronary Care Unit, Moscow City Hospital #1 named after N. Pirogov, Moscow, Russia.
an Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida.
ao Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, Alemania.
ap Department of Cardiology, Leiden University Medical Centre, Leiden, Países Bajos.
aq Division of Cardiovascular Diseases Mayo Clinic, Rochester, Minnesota.
ar Center for Molecular Cardiology, Schlieren Campus, University of Zurich, Suiza. Royal Brompton and Harefield Hospitals Trust and Imperial College, Londres, Reino Unido.
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        "resumen" => "<p class="elsevierStylePara"> ANTECEDENTES El pron&#243;stico del s&#237;ndrome de Takotsubo &#40;STT&#41; contin&#250;a siendo controvertido debido a la escasez de datos disponibles&#46; Adem&#225;s&#44; no se ha esclarecido todav&#237;a el efecto de los factores desencadenantes&#46;</p> <p class="elsevierStylePara"> OBJETIVOS En este estudio se compar&#243; el pron&#243;stico de pacientes con STT y con s&#237;ndrome coronario agudo &#40;SCA&#41; y se investigaron los resultados cl&#237;nicos a corto y largo plazo en el STT en funci&#243;n de los diferentes desencadenantes&#46;</p> <p class="elsevierStylePara"> M&#201;TODOS Se incluy&#243; en el estudio a pacientes con STT del <span class="elsevierStyleItalic">International Takotsubo Registry</span>&#46; Se compar&#243; la mortalidad a largo plazo de los pacientes con STT con la de una cohorte de pacientes con SCA emparejados por edad y sexo&#46; Se compararon asimismo los resultados cl&#237;nicos a corto y largo plazo de diferentes grupos de pacientes seg&#250;n los factores desencadenantes que mostraban&#46;</p> <p class="elsevierStylePara"> RESULTADOS En t&#233;rminos generales&#44; los pacientes con STT presentaron un riesgo de mortalidad a largo plazo comparable al de los pacientes con SCA&#46; De los 1613 pacientes con STT&#44; en 485 &#40;30&#37;&#41; se detect&#243; un desencadenante emocional&#46; De los 630 pacientes &#40;39&#37;&#41; con desencadenantes &#200;&#237;sicos&#44; 98 &#40;6&#37;&#41; ten&#237;an trastornos neurol&#243;gicos agudos&#44; mientras que en los otros 532 &#40;33&#37;&#41;&#44; los factores desencadenantes eran actividades &#200;&#237;sicas&#44; trastornos m&#233;dicos o intervenciones&#46; En los 498 pacientes restantes &#40;31&#37;&#41; no hab&#237;a ning&#250;n desencadenante identificable&#46; Los pacientes con un STT asociado a la tensi&#243;n &#200;&#237;sica mostraron unas tasas de mortalidad superiores a las de los pacientes con SCA durante el seguimiento a largo plazo&#44; mientras que los pacientes con un s&#237;ndrome asociado al estr&#233;s emocional presentaron una evoluci&#243;n cl&#237;nica mejor que la de los pacientes con SCA&#46;</p> <p class="elsevierStylePara"> CONCLUSIONES En t&#233;rminos generales&#44; los pacientes con STT tuvieron una evoluci&#243;n cl&#237;nica a largo plazo comparable a las de los pacientes con SCA de igual edad y sexo&#46; Demostramos&#44; adem&#225;s&#44; que el STT puede ser tanto un trastorno benigno como un trastorno que ponga en peligro la vida&#44; dependiendo de cu&#225;l sea el factor desencadenante&#46; Proponemos una nueva clasificaci&#243;n basada en los factores desencadenantes&#44; que puede ser una herramienta cl&#237;nica &#250;til para predecir la evoluci&#243;n a corto y a largo plazo del STT&#46; &#40;International Takotsubo Registry &#91;InterTAK Registry&#93;&#59; NCT01947621&#41; &#40;J Am Coll Cardiol 2018&#59;72&#58;874-82&#41; &#169; 2018 by the American College of Cardiology Foundation&#46; Publicado por Elsevier&#46;</p>"
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ISSN: X7351097
Idioma original: Español
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